Store your cash, credit cards, airline tickets and other valuables in a safe place. Most 4-star hotels have in-room safes, otherwise ask the reception to keep your valuable things in their deposit facility.
Take a hotel business card from the reception desk before venturing out from your hotel. This will make your return to the hotel in a taxi or cyclo much easier.
Carry a roll of toilet paper in your daypack on long excursions from your base hotel. You never know when you might need it!
Dress appropriately. Not only for the prevailing weather, but also not to cause offence to the local people. Vietnamese have conservative dress codes, and it is only in larger cities that these codes are a little more relaxed. Do not wear revealing clothing.
If invited into a Vietnamese home, always remove your shoes at the front door when entering.
Ask for permission when taking a photograph of someone. If they indicate that they do not want you to, then abide by their wishes.